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What is the difference between one injection, two injections and three injections of the new Crown vaccine?

Date:2021-07-15 Hits:290

Now everyone should have a clear feeling that vaccination stations all over the country have lined up long lines, and the supply of the new Crown vaccine is in short supply at that time. At present, there are three kinds of vaccines that are injected, namely single needle, double needle and three needle. In the previous publicity, most of the new Crown vaccines are double needle, the emergence of single-needle and three-needle vaccines has left many people at a loss. Below, Lekang Medical will take you to learn about these three vaccines:

In short, these three vaccines represent three different technical routes: one needle is an adenovirus vector vaccine, two needles are fire-fighting vaccines, and three needles are recombinant subunit vaccines. Which one did you play? I believe everyone is familiar with the names of some vaccines when making vaccines, so what kind of vaccines do they all belong?

The representatives of the inactivated vaccines of the two injections include: Beijing biology, Wuhan biology and Beijing Kexing;

The representative of the recombinant subunit vaccine of the three injections are: Zhifei biology.

The representatives of the adenovirus vector vaccine of one injection include: Konno biology.

Two-needle fire-fighting vaccine is the most classic form of vaccine, which is to "kill" and purify the new coronavirus cultured in vitro. The inactivated virus has no pathogenic ability, however, it can still stimulate the body to produce immune response and antibody in the body. Inactivated vaccines have good safety and effectiveness, and have been widely used in the vaccine production of other viruses at present.

Recombinant subunit vaccine (three needles) targets the receptor binding domain (RBD) of covid-s protein and induces human body to produce neutralizing antibodies through recombinant expression of RBD protein, so as to block the binding of coronavirus and ACE2, the host cell surface receptor, and achieve the purpose of preventing infection. Gene Recombination technology is adopted to express RBD protein specific antigen through mature CHO cell recombination. The technology is advanced and mature, it is similar to the production process of hepatitis B vaccine, HPV vaccine and hepatitis E vaccine.

Adenovirus vector vaccine (one needle) is a carrier vaccine in a new vaccine. It is the antigenic activity that transfers viral nucleic acid fragments to adeno-virus nucleic acid that has been safely processed to stimulate the immune effect of the body.

Features of the three vaccines:

The advantages of fire-fighting vaccine are that the preparation method is simple and rapid, and the safety is relatively high. However, the amount of inoculum is large, the immunization period is short, and the immunization route is relatively single. Overall, it is suitable for most people to be vaccinated.

Recombinant protein vaccine production does not require complete virus, is safe and reliable, easy to produce on a large scale, and has low cost. However, the disadvantage is that it needs three injections, and the vaccination cycle is relatively long, which is suitable for living in low-risk areas, people who have plenty of time are vaccinated.

The adenovirus vector vaccine needs to be injected with one dose without considering the inoculation interval, but the immune response intensity is generally weaker than that of two or three injections of vaccine, and there is no problem in preventing early epidemic viruses, when the virus is replaced with a late mutant virus, the protection efficiency will mostly decrease, which is more suitable for people who are temporarily or urgently considered to need to go to the epidemic area but do not have enough time to wait for vaccination.

Although the above three vaccines have different technical routes, they can all play a very good protective role against the new coronavirus, and they have been reviewed and approved by the drug regulatory authorities before listing. Their safety, effectiveness, all of them are supported by certain data, so you can be assured of vaccination.


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